Paracetamol (also known as acetaminophen) is a widely used over-the-counter medication for pain relief (analgesic) and fever reduction (antipyretic). In India the paracetamol is one the most commonest drug used. It is the most demanding drug in the market. The new “Made in India Paracetamol” to hit the market next year. This will be completely indigenous.
India is set to launch its domestically produced paracetamol by 2025, marking a significant step toward pharmaceutical self-reliance. The Council of Scientific and Industrial Research (CSIR) has developed an innovative and cost-effective technology for manufacturing paracetamol, aiming to reduce the country’s dependence on imported ingredients, primarily sourced from China.
Dr. N. Kalaiselvi, CSIR’s Director General, highlighted that this initiative is part of a broader strategy to transform India’s industrial innovation landscape and strengthen its position in the global supply chain. The Guwahati declaration by CSIR emphasizes the goal of making India a science and technology-driven global manufacturing hub by 2047.
Made in India Paracetamol
India has been a significant producer of pharmaceutical drugs, including paracetamol. Recent developments aim to enhance domestic production capacity for active pharmaceutical ingredients (APIs), reducing dependency on imports.
Key points regarding Made in India Paracetamol:
- Self-Reliance: Aligns with the “Make in India” initiative to boost local production.
- Cost Efficiency: New technologies are being developed to produce paracetamol at a reduced cost.
- Global Supply Chain: Strengthening India’s role in the global pharmaceutical market
This move aligns with India’s ongoing efforts to enhance domestic production of essential pharmaceuticals, ensuring greater self-sufficiency and resilience in the healthcare sector
Paracetamol is a key drug in the healthcare sector due to its efficacy and low side-effect profile when used in appropriate doses.
Uses
- Pain Relief: Effective for mild to moderate pain, including headaches, muscle aches, and toothaches.
- Fever Reduction: Commonly used to reduce fever in illnesses like the flu or common cold.
- Combination Medications: Often included in formulations with other drugs for managing symptoms of colds and flu.
Mechanism of Action
Paracetamol works by inhibiting the production of prostaglandins in the brain, which are chemicals that cause inflammation and pain. Unlike NSAIDs (e.g., ibuprofen), it has minimal anti-inflammatory effects.
Dosage
- Adults: 500 mg to 1000 mg every 4-6 hours as needed, with a maximum dose of 4000 mg per day.
- Children: Dosage depends on the child’s weight and age, usually 10-15 mg/kg every 4-6 hours.
Safety and Side Effects
- Safe in Recommended Doses: Well-tolerated in therapeutic doses.
- Liver Toxicity: Overdosing can lead to acute liver failure. This is especially risky in individuals with pre-existing liver conditions or those who consume alcohol regularly.
- Allergic Reactions: Rare but may include rash or swelling.
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